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KMID : 0363219720100020099
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Korean Journal of Dermatology
1972 Volume.10 No. 2 p.99 ~ p.105
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Xeroderma Pigmentosum
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Abstract
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Xeroderma pigmentosum is characterized by sunlight sensitivity, autosomal recessive inheritance, and multiple cutaneous malignancies, usually basal and squamous cell carcinomas.
In this work the effects of bleomycin and topical 5-fluorouracil on basal and squamous cell carcinomas appearing in the patient of xeroderma pigmentosum were studied and followed up for two years. The material was a 50 year old female patient of xeroderma pigmentosum associated with basal and squamous cell carcinomas occuring in the exposed area, and its mixed tumor in the nose for thirty years.
During first admission bleomycin was given intravenously in a dosage of 15 mg every other day or twice a week for basal cell carcinomas in the exposed area and mixed tumor in the nose. The total amount of bleomycin given was 315 mg.
A year later another squamous cell carcinomas developed on the exposed area. She was treated with topical application of 5% 5-fluorouracil cream daily for 40 days during second admission.
The results obtained are summarized as follows :
1. The effect of bleomycin is more effective in the squamous cell carcinoma than in the basal cell carcinoma which recurred after 2 years.
2. Topical therapy of 5% 5-fluorouracil cream appeared almost complete effectiveness to the squamous cell carcinoma.
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